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( A ) The concentration of fasting serum Galectin-3 in healthy controls (HC, n = 132), Ab − FDR ( n = 76), Ab + FDR ( n = 30), and patients with <t>T1D</t> ( n = 234). Data are expressed as median ± range. ( B ) The mRNA expression levels of Galectin-3 in CD14 + monocytes isolated from patients with T1D and HC ( n = 10), calculated using the 2 −△△Ct method. ( C ) The concentration of fasting serum LPS in HC and T1D groups ( n = 56). Data are expressed as median ± range. ( D ) Correlation between serum levels of Galectin-3 and LPS in HC and patients with T1D. ( E to J ) The THP-1 cell line, THP-1–cell induced macrophages, and the RAW 264.7 cell line were treated with LPS (100 ng/ml) or vehicle for 24 hours. The mRNA expression levels of Galectin-3 [(E), (G), and (I)] and the protein concentration of Galectin-3 in the supernatant [(F), (H), and (J)] were measured. Data in (E) to (J) are representative of at least three independent experiments with similar results. Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.
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( A ) The concentration of fasting serum Galectin-3 in healthy controls (HC, n = 132), Ab − FDR ( n = 76), Ab + FDR ( n = 30), and patients with T1D ( n = 234). Data are expressed as median ± range. ( B ) The mRNA expression levels of Galectin-3 in CD14 + monocytes isolated from patients with T1D and HC ( n = 10), calculated using the 2 −△△Ct method. ( C ) The concentration of fasting serum LPS in HC and T1D groups ( n = 56). Data are expressed as median ± range. ( D ) Correlation between serum levels of Galectin-3 and LPS in HC and patients with T1D. ( E to J ) The THP-1 cell line, THP-1–cell induced macrophages, and the RAW 264.7 cell line were treated with LPS (100 ng/ml) or vehicle for 24 hours. The mRNA expression levels of Galectin-3 [(E), (G), and (I)] and the protein concentration of Galectin-3 in the supernatant [(F), (H), and (J)] were measured. Data in (E) to (J) are representative of at least three independent experiments with similar results. Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.

Journal: Science Advances

Article Title: Galectin-3 exacerbates autoimmune diabetes by limiting regulatory T cell differentiation and function

doi: 10.1126/sciadv.adz7916

Figure Lengend Snippet: ( A ) The concentration of fasting serum Galectin-3 in healthy controls (HC, n = 132), Ab − FDR ( n = 76), Ab + FDR ( n = 30), and patients with T1D ( n = 234). Data are expressed as median ± range. ( B ) The mRNA expression levels of Galectin-3 in CD14 + monocytes isolated from patients with T1D and HC ( n = 10), calculated using the 2 −△△Ct method. ( C ) The concentration of fasting serum LPS in HC and T1D groups ( n = 56). Data are expressed as median ± range. ( D ) Correlation between serum levels of Galectin-3 and LPS in HC and patients with T1D. ( E to J ) The THP-1 cell line, THP-1–cell induced macrophages, and the RAW 264.7 cell line were treated with LPS (100 ng/ml) or vehicle for 24 hours. The mRNA expression levels of Galectin-3 [(E), (G), and (I)] and the protein concentration of Galectin-3 in the supernatant [(F), (H), and (J)] were measured. Data in (E) to (J) are representative of at least three independent experiments with similar results. Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.

Article Snippet: However, the significance of circulating Galectin-3 in type 1 diabetes (T1D) remains unclear.

Techniques: Concentration Assay, Expressing, Isolation, Protein Concentration